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M9550006.TXT
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1995-03-04
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Document 0006
DOCN M9550006
TI Inhibition of gp120-CD4 interaction and human immunodeficiency virus
type 1 infection in vitro by pyridoxal 5'-phosphate.
DT 9505
AU Guo L; Heinzinger NK; Stevenson M; Schopfer LM; Salhany JM; Department
of Pathology and Microbiology, University of Nebraska; Medical Center,
Omaha 68198-5120.
SO Antimicrob Agents Chemother. 1994 Oct;38(10):2483-7. Unique Identifier :
AIDSLINE MED/95142602
AB Pyridoxal 5'-phosphate and related compounds were tested for their
ability to inhibit gp120-CD4 interaction and human immunodeficiency
virus infection in vitro. The results show that pyridoxal 5'-phosphate
is a unique CD4 antagonist whose antiviral potency derives from the
presence of both lysine-reactive and anionic substituents.
DE Cells, Cultured CD4-Positive T-Lymphocytes/*METABOLISM
DIDS/PHARMACOLOGY DNA/BIOSYNTHESIS HIV Envelope Protein
gp120/*METABOLISM HIV-1/*DRUG EFFECTS Pyridoxal
Phosphate/*PHARMACOLOGY Reverse Transcriptase/ANTAGONISTS & INHIB
Support, Non-U.S. Gov't Support, U.S. Gov't, Non-P.H.S. Support, U.S.
Gov't, P.H.S. Virus Replication/DRUG EFFECTS JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).